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About Hemophilia
   
 
:: What is Hemophilia?

Hemophilia is a genetic disorder in which the patient bleeds excessively, usually only males are active sufferers while females are the carriers. The absence of deficiency of any clotting factor in blood usually factor VIII or factor IX, causes Hemophilia. Repeated bleeds in the joints and muscles unless promptly treated may lead to progressive disability and crippling. 

:: Classification of Hemophilia

:: Severe Hemophilia
:: Moderate Hemophilia
:: Mild Hemophilia ::

Severe Hemophilia:

If a person has no factor VIII or factor IX (<1%), his hemophilia is severe. Bleeds can happen without any obvious cause. This is called spontaneous bleeding. Bleeds can also happen after an injury. He may bleed several times per week. He will bleed more often and need more medical attention than a person with moderate hemophilia does.  ::

Moderate Hemophilia:

If a person has a small amount of factor VIII or factor IX (2%-5%), his hemophilia is moderate. He will most likely bleed less often than a person with severe hemophilia, and usually following an accident.

:: Mild Hemophilia:

If a person’s factor VIII or factor IX level is just a bit higher than in moderate hemophilia (6%-25%), but still below the level needed for a good clot, his hemophilia is mild. Unusual bleeding will only happen when people like this have a tooth taken out or when they have an operation or a big accident.

:: How dose bleeding stop?

The things in the blood that stop bleeding is called clotting factors. These clotting factors stop bleeding quickly in people who do not have hemophilia. When we bleed, a tear is made in a blood pathway. Right away ,the tube reacts by tightening up and special blood cells begin to close the hole. Then the clotting factors start to work to knit a cover for the hole. People who have hemophilia are missing one of these clotting factors, or one of them does not work properly. As a result, no cover is made for the hole.



:: Bleeding Types, Sites and Possibility

Types & Sites

Possibility

Joint Bleeding

70-80%

Ankle

Knee

Hip Joint

Elbow

Wrist Joint

Shoulders

Others

15%

45%

2%

30%

3%

3%

2%

Muscle Bleeding 10-20%
Other Bleeding 5-10%
Brain Hemorrhage <5%

:: Treatment of Hemophilia
          :: For Hemophilia A (Factor VIII Deficiency):

ð Anti Hemophilic Factor (Factor VIII) Injection

ð Cryoprecipitate ð FFP (Fresh Frozen Plasma)

ð Fresh Blood

:: For Hemophilia B (Factor IX Deficiency):

ð Anti Hemophilic Factor (Factor IX) Injection

ð PCC (Prothrombin Complex Concentrate)

ð FFP (Fresh Frozen Plasma)

ð Fresh Blood
 
 
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Hemophilia